Even when you send a file with the right 4x6 photo size, a lab can still trim a sliver off the edges. Two things cause it.
1. The ratio is close but not exact. Lab printers output to a full sheet of paper with no white border. If your file is only near 2:3 — say 1201×1800 px instead of 1200×1800 px — the machine scales it to fill the sheet and shaves off whatever falls outside. Export the exact pixel dimensions for your chosen PPI rather than an approximation.
2. Bleed and safe area. Photo printers cut the sheet after printing, and that cut is not perfectly precise. Most labs keep a safe margin of roughly 1/8 inch — about 40 px at 300 PPI — around the sheet. Anything important closer to the edge than that can lose a few pixels, which is invisible in a landscape but obvious when it clips a face or a line of text.
How to check before you send the file: look at the masked area in the crop preview above. If a head, a hand, or text sits within about 40 px of the frame edge, either reposition the crop or switch to Fit mode so the whole picture is kept. Portrait photos of people benefit most from this check, because a 4x6 portrait frame sits close to the subject on both sides.